新型磁共振成像納米膠束型磁共振造影劑的技術(shù)

核磁共振是一種**的非侵入性臨床診斷技術(shù)，但是受限于其靈敏度，針對(duì)**組織與正常組織微環(huán)境間的差異，特別是微小溫度差異的檢測(cè)并不能取得很好的效果。

發(fā)展了一種對(duì)生理溫度范圍內(nèi)微小溫度差異進(jìn)行檢測(cè)的新方法。研究者制備了一種納米膠束型磁共振造影劑增強(qiáng)其靈敏度，該種造影劑能在人體生理溫度范圍內(nèi)對(duì)微小的溫度變化做出響應(yīng)。利用熱敏型膠束作為載體，研究者們?cè)O(shè)計(jì)了這種基于化學(xué)交換飽和轉(zhuǎn)移成像的納米磁共振造影劑。這種直徑小于100納米的膠束粒子在37度發(fā)生結(jié)構(gòu)和形態(tài)的變化，改變了造影劑所攜帶結(jié)合水所在微環(huán)境的化學(xué)交換速率，進(jìn)而使得其化學(xué)交換飽和轉(zhuǎn)移效應(yīng)發(fā)生了明顯的改變。通過(guò)化學(xué)交換飽和轉(zhuǎn)移成像方法，研究者們獲得這種溫度敏感型造影劑對(duì)不同溫度時(shí)信號(hào)的智能放大。由于響應(yīng)的溫度范圍接近人體生理溫度，使得該造影劑在臨床應(yīng)用上具有重要意義。

產(chǎn)品供應(yīng)：

影像對(duì)比劑

活體熒光造影劑

Sulfo-CY7(Cyanine7) NHSester活體熒光造影劑

Sulfo-CY7-NHS,Sulfo-Cyanine7.5NHSester,Comparisonofcyanine(Cy)dyesusedinlifescienceaslabelsformolecularbiologyanddiagnostics

sulfo-CY7(Cyanine7) maleimide活體熒光造影劑

sulfo-CY7-MAL,sulfo-Cyanine7.5maleimide,Comparisonofcyanine(Cy)dyesusedinlifescienceaslabelsformolecularbiologyanddiagnostics

Sulfo-CY7(Cyanine7) dicarboxylicacid活體熒光造影劑

Sulfo-Cyanine7.5dicarboxylicacid,Comparisonofcyanine(Cy)dyesusedinlifescienceaslabelsformolecularbiologyanddiagnostics

Sulfo-CY7(Cyanine7) carboxylicacid活體熒光造影劑

Sulfo-Cy7COOHSulfo-Cyanine7.5carboxylicacid,Comparisonofcyanine(Cy)dyesusedinlifescienceaslabelsformolecularbiologyanddiagnostics

Sulfo-CY7(Cyanine7) azide活體熒光造影劑

Sulfo-CY7/N3,Sulfo-Cyanine7.5azide,Comparisonofcyanine(Cy)dyesusedinlifescienceaslabelsformolecularbiologyanddiagnostics

Sulfo-CY7(Cyanine7) alkyne活體熒光造影劑

Sulfo-CY7-alkyne,Sulfo-Cyanine7.5alkyne,Comparisonofcyanine(Cy)dyesusedinlifescienceaslabelsformolecularbiologyanddiagnostics

Sulfo-CY7(Cyanine7) tetrazine活體熒光造影劑

Sulfo-Cyanine7tetrazine,Comparisonofcyanine(Cy)dyesusedinlifescienceaslabelsformolecularbiologyanddiagnostics

Sulfo-CY7(Cyanine7) NHSester活體熒光造影劑

Sulfo-Cyanine7NHSester,Comparisonofcyanine(Cy)dyesusedinlifescienceaslabelsformolecularbiologyanddiagnostics

Sulfo-CY7(Cyanine7) maleimide活體熒光造影劑

Sulfo-Cyanine7maleimide,Comparisonofcyanine(Cy)dyesusedinlifescienceaslabelsformolecularbiologyanddiagnostics

sulfo-CY7(Cyanine7) dicarboxylicacid活體熒光造影劑

sulfo-Cyanine7dicarboxylicacid,Comparisonofcyanine(Cy)dyesusedinlifescienceaslabelsformolecularbiologyanddiagnostics

Sulfo-CY7(Cyanine7) carboxylicacid活體熒光造影劑

Sulfo-Cyanine7carboxylicacid,Comparisonofcyanine(Cy)dyesusedinlifescienceaslabelsformolecularbiologyanddiagnostics

Sulfo-CY7(Cyanine7) bis-NHSester活體熒光造影劑

Sulfo-Cyanine7bis-NHSester,Comparisonofcyanine(Cy)dyesusedinlifescienceaslabelsformolecularbiologyanddiagnostics

Sulfo-CY7(Cyanine7) azide活體熒光造影劑

Sulfo-Cyanine7azide,Comparisonofcyanine(Cy)dyesusedinlifescienceaslabelsformolecularbiologyanddiagnostics

Sulfo-CY7(Cyanine7) amine活體熒光造影劑

Sulfo-Cyanine7amine,Comparisonofcyanine(Cy)dyesusedinlifescienceaslabelsformolecularbiologyanddiagnostics

Sulfo-CY7(Cyanine7) alkyne活體熒光造影劑

Sulfo-Cyanine7alkyne,Comparisonofcyanine(Cy)dyesusedinlifescienceaslabelsformolecularbiologyanddiagnostics

CY7(Cyanine7) tetrazine活體熒光造影劑

Cyanine7.5tetrazine,Comparisonofcyanine(Cy)dyesusedinlifescienceaslabelsformolecularbiologyanddiagnostics

CY7(Cyanine7) NHSester活體熒光造影劑

Cyanine7.5NHSester,Comparisonofcyanine(Cy)dyesusedinlifescienceaslabelsformolecularbiologyanddiagnostics

CY7(Cyanine7) maleimide活體熒光造影劑

Cyanine7.5maleimide,Comparisonofcyanine(Cy)dyesusedinlifescienceaslabelsformolecularbiologyanddiagnostics

CY7(Cyanine7) hydrazide活體熒光造影劑

Cyanine7.5hydrazide,Comparisonofcyanine(Cy)dyesusedinlifescienceaslabelsformolecularbiologyanddiagnostics

CY7(Cyanine7) carboxylicacid活體熒光造影劑

Cyanine7.5carboxylicacid,Comparisonofcyanine(Cy)dyesusedinlifescienceaslabelsformolecularbiologyanddiagnostics

CY7 (Cyanine7) azide活體熒光造影劑

Cyanine7.5azide,Comparisonofcyanine(Cy)dyesusedinlifescienceaslabelsformolecularbiologyanddiagnostics

CY7 (Cyanine7) azide,10mM/DMSO活體熒光造影劑

Cyanine7.5azide,10mM/DMSO,Comparisonofcyanine(Cy)dyesusedinlifescienceaslabelsformolecularbiologyanddiagnostics

CY7(Cyanine7) amine活體熒光造影劑

Cyanine7.5amine,Comparisonofcyanine(Cy)dyesusedinlifescienceaslabelsformolecularbiologyanddiagnostics

CY7(Cyanine7) alkyne活體熒光造影劑

Cyanine7.5alkyne,Comparisonofcyanine(Cy)dyesusedinlifescienceaslabelsformolecularbiologyanddiagnostics

CY7(Cyanine7) tetrazine活體熒光造影劑

Cyanine7tetrazine,Comparisonofcyanine(Cy)dyesusedinlifescienceaslabelsformolecularbiologyanddiagnostics

CY7(Cyanine7) NHSester活體熒光造影劑

Cyanine7NHSester,Comparisonofcyanine(Cy)dyesusedinlifescienceaslabelsformolecularbiologyanddiagnostics

CY7(Cyanine7) maleimide活體熒光造影劑

Cyanine7maleimide,Comparisonofcyanine(Cy)dyesusedinlifescienceaslabelsformolecularbiologyanddiagnostics

CY7(Cyanine7) hydrazide活體熒光造影劑

Cyanine7hydrazide,Comparisonofcyanine(Cy)dyesusedinlifescienceaslabelsformolecularbiologyanddiagnostics

CY7(Cyanine7) dicarboxylicacid活體熒光造影劑

Cyanine7dicarboxylicacid,Comparisonofcyanine(Cy)dyesusedinlifescienceaslabelsformolecularbiologyanddiagnostics

CY7(Cyanine7) DBCO活體熒光造影劑

Cyanine7DBCO,Comparisonofcyanine(Cy)dyesusedinlifescienceaslabelsformolecularbiologyanddiagnostics

CY7(Cyanine7) carboxylicacid活體熒光造影劑

Cyanine7carboxylicacid,Comparisonofcyanine(Cy)dyesusedinlifescienceaslabelsformolecularbiologyanddiagnostics

CY7(Cyanine7) azide活體熒光造影劑

Cyanine7azide,Comparisonofcyanine(Cy)dyesusedinlifescienceaslabelsformolecularbiologyanddiagnostics

CY7(Cyanine7) azide,10mM/DMSO活體熒光造影劑

Cyanine7azide,10mM/DMSO,Comparisonofcyanine(Cy)dyesusedinlifescienceaslabelsformolecularbiologyanddiagnostics

CY7(Cyanine7) amine活體熒光造影劑

Cyanine7amine,Comparisonofcyanine(Cy)dyesusedinlifescienceaslabelsformolecularbiologyanddiagnostics

CY7(Cyanine7) alkyne活體熒光造影劑

Cyanine7alkyne,Comparisonofcyanine(Cy)dyesusedinlifescienceaslabelsformolecularbiologyanddiagnostics

BDP650/665XNHSester活體熒光造影劑

BDP650/665XNHSester,Borondipyrromethenedyeforfluorescein(516nm)channel-verybrightandphotostablefluorophore.

BDP650/665maleimide活體熒光造影劑

BDP650/665maleimide,Borondipyrromethenedyeforfluorescein(515nm)channel-verybrightandphotostablefluorophore.

BDP650/665azide活體熒光造影劑

BDP650/665azide,Borondipyrromethenedyeforfluorescein(514nm)channel-verybrightandphotostablefluorophore.

BDP650/665alkyne活體熒光造影劑

BDP650/665alkyne,Borondipyrromethenedyeforfluorescein(513nm)channel-verybrightandphotostablefluorophore.

BDP630/650XNHSester活體熒光造影劑

BDP630/650XNHSester,Borondipyrromethenedyeforfluorescein(512nm)channel-verybrightandphotostablefluorophore.

BDP630/650tetrazine活體熒光造影劑

BDP630/650tetrazine,Borondipyrromethenedyeforfluorescein(511nm)channel-verybrightandphotostablefluorophore.

BDP630/650maleimide活體熒光造影劑

BDP630/650maleimide,Borondipyrromethenedyeforfluorescein(510nm)channel-verybrightandphotostablefluorophore.

BDP630/650hydrazide活體熒光造影劑

BDP630/650hydrazide,Borondipyrromethenedyeforfluorescein(509nm)channel-verybrightandphotostablefluorophore.

BDP630/650carboxylicacid活體熒光造影劑

BDP630/650carboxylicacid,Borondipyrromethenedyeforfluorescein(508nm)channel-verybrightandphotostablefluorophore.

BDP630/650azide活體熒光造影劑

BDP630/650azide,Borondipyrromethenedyeforfluorescein(507nm)channel-verybrightandphotostablefluorophore.

BDP630/650amine活體熒光造影劑

BDP630/650amine,Borondipyrromethenedyeforfluorescein(506nm)channel-verybrightandphotostablefluorophore.

BDP630/650alkyne活體熒光造影劑

BDP630/650alkyne,Borondipyrromethenedyeforfluorescein(505nm)channel-verybrightandphotostablefluorophore.

T2型造影劑-超順磁性四氧化三鐵顆粒（USPIO/SPIO）

T2對(duì)比劑（順磁性鐵錳）

普魯士藍(lán)納米顆粒

普魯士藍(lán)納米顆粒；純水溶液；粒徑：100nm

親和素表面磁性氧化鐵微球（1um）

1um親和素包裹的磁性四氧化三鐵微球；純水溶液；粒徑：1±0.1um

羧基表面磁性氧化鐵微球（1um）

1um羧基化磁微球；純水溶液；粒徑：1±0.1um

磁性氧化鐵納米球（500nm）

500nm磁性氧化鐵納米球；純水溶液；粒徑：300±50nm

磁性氧化鐵納米球（300nm）

300nm磁性氧化鐵納米球；純水溶液；粒徑：300±50nm

磁性氧化鐵納米球（200nm）

200nm磁性氧化鐵納米球；純水溶液；粒徑：200±50nm

PEG化磁性錳鋅鐵氧體納米晶（氨基）

PEG化磁性錳鋅鐵氧體納米晶（-NH2）；純水溶液；粒徑：10±5nm

PEG化磁性錳鋅鐵氧體納米晶（羧基）

PEG化磁性錳鋅鐵氧體納米晶（-COOH）；純水溶液；粒徑：10±5nm

PEG化磁性錳鋅鐵氧體納米晶（甲氧基）

PEG化磁性錳鋅鐵氧體納米晶（-OCH3）；純水溶液；粒徑：10±5nm

錳鋅鐵氧體納米晶

錳鋅鐵氧體納米晶（高溫?zé)峤夥ǎ宦确氯芤海涣剑?5±5nm

熒光素標(biāo)記Fe3O4顆粒;USPIO;SA-DSPE-PEG-Fe3O4

熒光素修飾的四氧化三鐵磁性納米顆粒（FITC-Fe3O4）；純水溶液；粒徑：10±5nm

親和素表面Fe3O4顆粒SA-DSPE-PEG-Fe3O4;10nm

鏈霉親和素修飾的四氧化三鐵磁性納米顆粒（SA-Fe3O4）；純水溶液；粒徑：10±5nm

氨基端PEG化Fe3O4顆粒;DSPE-PEG-Fe3O4（-NH2）;10nm

PEG化四氧化三鐵磁性納米顆粒（-NH2）；純水溶液；粒徑：10±5nm

羧基端PEG化Fe3O4顆粒;DSPE-PEG-Fe3O4（-COOH）;10nm

PEG化四氧化三鐵磁性納米顆粒（-COOH）；純水溶液；粒徑：10±5nm

甲氧基PEG化Fe3O4顆粒;DSPE-PEG-Fe3O4（-CH3O）；50nm

PEG化四氧化三鐵磁性納米顆粒（-OCH3）；氯仿溶液；粒徑：50±5nm

PEG化Fe3O4顆粒;25nm;PEG-Fe3O4

PEG化四氧化三鐵磁性納米顆粒（-OCH3）；純水溶液；粒徑：25±5nm

PEG化Fe3O4顆粒;PEG-USPIO；10nm

PEG化四氧化三鐵磁性納米顆粒（-OCH3）；純水溶液；粒徑：10±5nm

油酸表面Fe3O4顆粒氯仿溶液;OA-Fe3O4-C

油酸修飾的四氧化三鐵磁性納米顆粒（OA-Fe3O4，高溫?zé)峤夥ǎ宦确氯芤海涣剑?0±5nm

油酸表面Fe3O4顆粒粉末;OA-USPIO

油酸修飾的四氧化三鐵磁性納米顆粒（OA-Fe3O4，高溫?zé)峤夥ǎ还腆w粉末；粒徑：10±5nm

磁性石墨烯;MagneticGR

磁性石墨烯溶液（500mg）

載USPIO聚苯乙烯納米粒

磁性聚苯乙烯納米球（PS-Fe3O4）；純水溶液；粒徑：100±50nm

二氧化硅表面Fe3O4顆粒;SiO2-Fe3O4

二氧化硅修飾的四氧化三鐵磁性納米顆粒（SiO2-Fe3O4）；純水溶液；粒徑：10±5nm

羧基表面Fe3O4顆粒;DMSA-USPIO

羧基化四氧化三鐵磁性納米顆粒（DMSA-Fe3O4）；純水溶液；粒徑：10±5nm

PEI氨基表面Fe3O4顆粒;PEI-USPIO

聚乙烯亞胺修飾的四氧化三鐵磁性納米顆粒（PEI-Fe3O4）；純水溶液；粒徑：10±5nm

油酸表面Fe3O4顆粒;OA-USPIO

油酸修飾的四氧化三鐵磁性納米顆粒（OA-Fe3O4，共沉淀法）；純水溶液；粒徑：10±5nm

氨基表面Fe2O3顆粒；APTS-Fe2O3

氨基化三氧化二鐵磁性納米顆粒（APTS-Fe2O3）；純水溶液；粒徑：10±5nm

羧基表面Fe2O3顆粒；DMSA-Fe2O3

羧基化三氧化二鐵磁性納米顆粒（DMSA-Fe2O3)；純水溶液；粒徑：10±5nm

PLL修飾Fe2O3顆粒

PLL-Fe2O3多聚賴氨酸修飾的三氧化二鐵磁性納米顆粒（PLL-Fe2O3）；純水溶液；粒徑：10±5nm

γ-Fe2O3

伽馬-三氧化二鐵磁性納米顆粒（γ-Fe2O3）；純水溶液；粒徑：10±5nm

上述產(chǎn)品齊岳生物均可供應(yīng)，僅用于科研！

wyf 04.05